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. 2013 Aug 27;123(9):4036–4049. doi: 10.1172/JCI69031

Figure 8. p.Arg497* mutation results in phenotypic changes in the cellular structures of various organs.

Figure 8

Hematoxylin and eosin staining of paraffin-embedded sections of the various organs of (A, D, G, and J) Tric+/+ (n = 5), (B, E, H, and K) TricR497X/+ (n = 6), and (C, F, I, and L) TricR497X/R497X (n = 6) mice. Images are of (A–C) mandibular salivary glands of male mice, (D–F) mandibular salivary glands of female mice, (G–I) thyroid glands, and (J–L) hearts. In general, the TricR497X/R497X males appeared to have a decrease in the number of granules in the mandibular salivary gland, while females had a depletion of granules. The thyroid glands of TricR497X/R497X mice had a significantly elevated number of ectatic follicles (P < 0.05), and there was a higher number of myocytes with enlarged nuclei (arrows) in the TricR497X+ and TricR497X/R497X mice. Scale bar: 50 μm.