Skip to main content
. 2013 Aug 5;123(9):3756–3765. doi: 10.1172/JCI69098

Figure 4. Polyfunctional tumor-reactive CD8+ T cell responses are induced following early posttransplant CLL/GM-K562 cell vaccination.

Figure 4

Functional capacity of CD8+ T cells isolated at serial pre- and post-HSCT time points from (A) VAX5–6 (n = 6), (B) VAX1–3/GvHD (n = 4) study subjects, or (C) control patients (with RIC allo-HSCT for advanced CLL, but without vaccine or GvHD within the first 100 days after transplantation; n = 5) in response to autologous tumor cells was analyzed by simultaneous assessment of secreted GM-CSF, TNF-α, IL-2, and IL-10. Bars represent the median concentration of the corresponding cytokine in pg/ml. Individual values are depicted as black circles. *P < 0.05 (VAX5–6 vs. control group and VAX5–6 vs. VAX1–3/GvHD group CD8+ T cell reactivity; 2-sided Wilcoxon rank-sum test).