Table 1.
Effect of CmeABC PNAs on the susceptibility of C. jejuni to ciprofloxacin and erythromycin
| C. jejuni strain and treatment | PNA concn (μM) | MIC (mg/liter)a |
|
|---|---|---|---|
| Ciprofloxacin | Erythromycin | ||
| NCTC 11168 | |||
| No PNA | 0.125 | 0.25 | |
| Negative-control PNA | 4 | 0.125 | 0.25 |
| CmeA PNA | 4 | 0.0625 (2) | 0.125 (2) |
| CmeB PNA | 4 | 0.0625 (2) | 0.125 (2) |
| CmeC PNAs | 4 | 0.125 | 0.25 |
| CmeA + CmeB PNAs | 1 | 0.0075 (16) | 0.0625 (4) |
| 2 | <0.00375 (>32) | 0.0156 (16) | |
| 4 | <0.00375 (>32) | <0.0075 (>32) | |
| 62301R33 | |||
| No PNA | 16 | NT | |
| CmeA PNA | 2 | 2 (8) | NT |
| CmeB PNA | 2 | 8 (2) | NT |
| CmeA + CmeB PNAs | 2 | 1 (16) | NT |
| JL272 | |||
| No PNA | NT | 512 | |
| CmeA PNA | 2 | NT | 256 (2) |
| CmeB PNA | 2 | NT | 256 (2) |
| CmeA + CmeB PNAs | 2 | NT | 128 (4) |
a
The numbers in parentheses indicate the fold changes in the MIC compared with the MIC for cells with no PNAs. NT, not tested.