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CD4-dependent and -independent fusion entry of wild-type and mutant LAI envelopes. Emission of light based on luciferase levels following fusion of wild-type LAI (LAI/WT) with ACTOne-CXCR4 cells was ∼200 RLU (negative controls using mock-transfected cells did not produce a measurable signal) and was equivalent to that following fusion of L116P virus with ACTOne-CXCR4 cells. The bars represent the mean values of two independent experiments. Standard deviations are shown as error bars.
