Table 2.
Effects of HIV-1 entry inhibitors on CD4-dependent and CD4-independent, CXCR4-dependent entrya
| HIV-1 entry inhibitor | Target | Inhibition | Mean EC50 (nM) ± SDb |
|||
|---|---|---|---|---|---|---|
| HeLa CD4/CCR5/CXCR4 |
ACTOne-CXCR4 |
|||||
| LAI | HIV-8x | LAI | HIV-8x | |||
| BMS-626529 | gp120 | gp120-CD4 interaction | 0.9 ± 0.4 | 97 ± 14 | No infection | 17 ± 6 |
| Ibalizumab | CD4 | gp120-coreceptor interaction | 1.6 ± 0.2 | >4,990 | No infection | >4,950 |
| AMD-3100 | CXCR4 | gp120-CXCR4 interaction | 16 ± 2.0 | 79 ± 18 | No infection | 35 ± 18 |
| ENF | gp41 | gp41 hairpin formation | 9.7 ± 2.2 | 650 ± 123 | No infection | 125 ± 44.5 |
a
LAI, CD4 dependent, CXCR4 dependent; HIV-8x, CD4 independent, CXCR4 dependent.
b
Mean values of three independent experiments.