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Effects of restoration of the cytoplasmic tail and G431E substitution on the susceptibility of HIV-8x to BMS-626529
| HIV-1 entry inhibitor | Mean EC50 (nM) ± SDa |
|||||
|---|---|---|---|---|---|---|
| HeLa CD4/CCR5/CXCR4 |
ACTOne-CXCR4 |
|||||
| HIV-8x wild type | HIV-8x with tail | HIV-8x G431E | HIV-8x wild type | HIV-8x with tail | HIV-8x G431E | |
| BMS-626529 | 97 ± 14 | 12 ± 0.6 | 131 ± 33 | 106 ± 25 | No infection | No infection |
| AMD-3100 | 79 ± 18 | 15 ± 11 | 12 ± 6 | 30 ± 15 | No infection | No infection |
Mean values of two independent experiments.
