Table 4.
Confirmation that BMS-626529 inhibits ADA S190R/N197S virus infection of ACTOne-CCR5 cells by a mechanism consistent with an AI
| HIV-1 entry inhibitor | Mean EC50 (nM) ± SDa |
|||||||
|---|---|---|---|---|---|---|---|---|
| HeLa CD4/CCR5/CXCR4 |
ACTOne-CCR5 |
|||||||
| ADA |
ADA S190R/N197S |
ADA |
ADA S190R/N197S |
|||||
| M426 | L426 | M426 | L426 | M426 | L426 | M426 | L426 | |
| BMS-626529 | 0.2 ± 0.0 | 36 ± 3 | 0.9 ± 0.2 | 78 ± 5 | No infection | No infection | 1 ± 0.4 | 57 ± 10 |
| MVC | 0.8 ± 0.5 | 0.5 ± 0.0 | 0.9 ± 0.2 | 0.7 ± 0.1 | No infection | No infection | 1 ± 0.6 | 0.4 ± 0.1 |
a
Mean values of two independent experiments.