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Susceptibility of ENF-resistant virus and clinical envelopes to BMS-626529 determined by a pseudotype virus assaya
| Substitution | BMS-626529 |
Enfuvirtide |
||
|---|---|---|---|---|
| Mean IC50 (nM) ± SD | FC-IC50 | Mean IC50 (nM) ± SD | FC-IC50 | |
| Wild type | 0.1 ± 0.06 | 1 | 2 ± 0.2 | 1 |
| G36D | 0.2 ± 0.03 | 2 | 154 ± 15 | 77 |
| V38A | 0.1 ± 0.004 | 1 | 481 ± 75 | 240 |
| Q40H | 0.1 ± 0.02 | 1 | 11 ± 2 | 5.5 |
| N42T | 0.1 ± 0.01 | 1 | 26 ± 0.4 | 13 |
| N43D | 0.1 ± 0.09 | 1 | 302 ± 20 | 151 |
Mean values of two independent experiments are shown.
