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Emergence of resistance during drug administration. (A) Negative control (no treatment) and active controls (ceftolozane at 375 mg every 8 h [Q8h] and piperacillin [PIP]-tazobactam at 4.5 g every 6 h). (B) Ceftolozane-tazobactam (TOL/TAZ) dosing regimens ranging from 125-62.5 to 1,500-750 mg infused every 8 h.
