Table 3.
Statistical analysis of DTG PK parameters
| Parameter | Ratio of geometric least-square means (90% CI) |
|
|---|---|---|
| DTG plus prednisone (day 5) vs DTGa | DTG plus prednisone (day 10) vs DTGb | |
| AUC0–τ | 1.13 (1.04, 1.21) | 1.11 (1.03, 1.20) |
| Cmax | 1.05 (0.98, 1.12) | 1.06 (0.99, 1.14) |
| Cmin | 1.08 (0.99, 1.17) | 1.07 (0.98, 1.16) |
| Cτ | 1.21 (1.10, 1.32) | 1.17 (1.06, 1.28) |
| CL/F | 0.89 (0.82, 0.96) | 0.90 (0.84, 0.97) |
| t1/2 | 1.11 (1.00, 1.22) | 1.07 (0.97, 1.18) |
a
PK parameters after 5 days of treatment with DTG (50 mg daily) versus DTG and prednisone (60 mg daily). Values were calculated based on data from 12 subjects.
b
PK parameters after 5 days of treatment with DTG (50 mg daily) versus 5 days of treatment with DTG and prednisone (60 mg daily) followed by 5 days of tapering prednisone doses (10-mg taper each day). Values were calculated based on data from 12 subjects.