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EVG susceptibility of pseudoviruses engineered by site-directed mutagenesis (SDMs) containing Y143X substitutions alone or in combination with additional RAL resistance-associated secondary substitutions. Susceptibility was measured using the PhenoSense Integrase assay and expressed as FC in EC50 relative to the wild-type reference virus. EVG FC results are expressed as the means of duplicates of each mutant. The FC variation between duplicates of each mutant was <1.5.
