Table 2.
Frequency of the secondary substitutions among 77 viruses containing Y143R, Y143C, and Y143A,G,H,Sa
| Y143 substitution (no. of samples) | No. (%) of samples with secondary substitution: |
Avg no. of secondary substitutions per sample | ||||||
|---|---|---|---|---|---|---|---|---|
| L74M(I) | E92Q | T97A | E138K | G163R | I203M | S230R | ||
| Y143R (n = 44) | 7 (16) | 0 (0) | 32 (73) | 3 (7) | 8 (18) | 3 (7) | 0 (0) | 1.2 |
| Y143C (n = 23) | 10 (43) | 2 (9) | 17 (74) | 0 (0) | 5 (22) | 1 (4) | 18 (78) | 2.3 |
| Y143A/H/G/S (n = 10) | 6 (60) | 1 (10) | 8 (80) | 0 (0) | 3 (33) | 1 (10) | 2 (20) | 2.1 |
| Total no. of substitutions (n = 77) | 23 (30) | 3 (4) | 57 (74) | 3 (4) | 16 (21) | 5 (6) | 20 (26) | 1.6 |
a
Bold font designates a high prevalence of secondary substitutions found in specific Y143X patient virus groups. Y143C and Y143A,H,G,S viruses contain more secondary substitutions than do Y143R viruses (P < 0.001; Wilcoxon's test).