Fig 8.

In vivo anti-influenza virus activities of S0 and S3 in the lethal mouse model. Mice were infected with a lethal dose of A/PR8 virus (5× MLD₅₀) and treated with DMSO-PBS (16% [vol/vol]), ribavirin (75 mg/kg/day), S0 (25 mg/kg/day), or S3 (25 mg/kg/day) for 10 days from day 0. (A) Survival curves of infected mice (n = 10). The results are expressed as the percent survival evaluated daily for 21 days. (B) Influenza virus titers in the lungs of mice at day 6 postinfection. Virus titers in lung homogenates were determined as described in Materials and Methods. The data are expressed as the means ± SD of three independent experiments. **, P < 0.01 versus the untreated group.