Fig 2.

Activation of hCAR by antiretroviral drugs. Representative data from three independent dual-luciferase reporter gene assays performed with transfected primary cultures of mouse hepatocytes after 14 to 16 h of treatment with antiretroviral drugs (10 μM) are presented as means ± SDs of triplicates. Luciferase activity (representing ligand activation) was normalized to constitutive Renilla luciferase activity (to control for transfection efficiency) and is reported in RLU. Statistically significant differences in receptor activation (normalized to the vehicle control) were determined by one-way ANOVA with Dunnett's post hoc test at a significance level of P < 0.05 (*).