Fig 4.

Decreased level of UppS increases susceptibility to late-acting cell wall antibiotics. (A) Schematic representation of the bacterial peptidoglycan synthesis pathway, related genes, and cell wall antibiotics that interfere with specific steps. (B) Effect of the uppS1 allele on susceptibility to late-acting cell wall antibiotics. Disk diffusion assays were performed on MH agar plates with filter paper disks containing different types of antibiotics. Each bar represents the average zone of inhibition, expressed as total diameter minus diameter of the filter paper disk (6.5 mm). Three independent experiments were performed for each strain. Error bars indicate standard deviations.