Table 1.

Polymorphisms in the linker region sequence of 215 P. falciparum isolates and the proportion in each class linked to the codon 86Y, codon 184F, and codon 1246Y alleles^a

Asn-Asp-Asnb	No. of polymorphisms in the linker region sequence of isolates from the following country:					Proportion (%) in each class linked to the following pfmdr1 allelec:
	Sudan	Kenya	Burkina	The Gambia	All four countries (total)	86Y	184F	1246Yd
7-2-09	39	10	29	4	82	52	73	4 (47)
7-2-10	6	34	12	1	53	65	22	50 (40)
7-2-07	0	8	12	0	20	0	55	0 (8)
8-2-09	0	3	13	0	16	69	88	0 (3)
7-2-08	0	1	4	6	11	18	64	0 (1)
7-0-02	0	7	2	0	9	33	44	0 (7)
7-0-04	0	8	0	0	8	50	100	50 (8)
7-0-01	1	6	0	0	7	86	14	71 (7)
7-2-11	0	1	6	0	7	14	57	100 (1)
7-2-06	0	0	1	5	6	0	83
8-2-08	0	0	0	5	5	100	100
8-1-09	0	0	2	1	3	0	0
5-2-09	0	0	2	0	2	0	0
7-0-03	1	0	1	0	2	50	50	0 (1)
7-0-00	0	0	0	1	1	0	100
7-0-06	0	1	0	0	1	0	0	0 (1)
7-1-11	0	1	0	0	1	0	0	0 (1)
7-2-01	0	0	0	1	1	0	0
7-2-04	0	0	1	0	1	0	100
7-2-05	0	0	0	1	1	0	100
7-2-12	0	0	1	0	1	100	100
7-2-15	0	0	1	0	1	0	100
8-0-00	0	0	0	1	1	100	100
8-2-10	0	0	1	0	1	0	0
Total	47	80	88	26	241	236	234	125

^aThe total number of linker region sequences determined from the different countries and the total number of samples evaluated for each pfmdr1 allele are shown in boldface type.

^bNumbers of Asn, Asp, and Asn residues in the linker sequence, respectively.

^cSequence data at each codon were not available for all isolates. Thus, the denominator for the codon analyses is less than 236 in each case. For codon 1246, only samples from Kenya and Sudan were included in the analysis (see the text).

^dThe number of samples is shown in parentheses.