Table 3.

Pharmacokinetic parameters of mefloquine and enpiroline following oral administration to mice infected or not infected with S. mansoni

Parameter	Mean value (n = 3 mice/time point) for mice treated (200 mg/kg) with:
	Mefloquine		Enpiroline
	S. mansoni infected	Noninfected	S. mansoni infected	Noninfected
t1/2 (h)	182.7	33.6	182.1	72.0
AUC0-168 (ng · h/ml)	567,845.5	503,623.5	819,557.5	859,603
AUC0-∞ (ng · h/ml)	1,116,517.8	522,409.1	1,790,287.1	1,107,982.3
Cmax (ng/ml)	7,238	10,223	5,746	7,641
Tmax (h)	12	12	24	48