Table 1. Characterization of XBP1s- and/or ATF6-Remodeled ER Proteostasis Environments.

	Fold Change in Arraysa			Fold Change in Proteomicsb,c
Protein	XBP1s	ATF6	Both	XBP1s	ATF6	Both
ER Import
Sec61A1	2.14	NS	1.95	ND	ND	ND
SRPR	1.98	NS	1.84	NS	NS	NS
SRPRB	1.99	NS	1.86	2.1	NS	1.7
SRP19	2.43	NS	2.11	NS	NS	NS
Hsp40/70/90
GRP78 (BiP)	NS	2.24	2.30	1.6 (1.6)	4.1 (4.5)	3.9 (4.5)
GRP94	NS	NS	1.26	1.3 (2.0)	2.3 (4.7)	2.2 (4.1)
P58/IPK	2.34	2.36	3.26	NS	1.5	2.2
ERDJ3	1.51	1.94	1.91	ND (1.3)	ND (1.2)	ND (1.5)
ERDJ4	4.89	NS	5.07	ND	ND	ND
ERDJ5	1.69	NS	1.92	NS	NS	1.8
HYOU1	3.37	4.64	6.32	1.7 (1.7)	2.5 (2.0)	3.1 (2.6)
N-Glycosylation and Lectin-Assisted Folding
STT3A	1.80	NS	1.75	NS	NS	NS
DDOST	NS	NS	NS	1.3	NS	NS
RPN1	1.64	NS	1.76	1.4	NS	1.2
CANX	1.21	NS	1.29	1.2	NS	NS
CRT	1.38	2.22	2.09	1.2	1.6	1.6
LMAN1 (ERGIC53)	1.66	NS	1.52	1.7	NS	1.5
Disulfide Redox
PDIA3 (ERP57)	1.62	1.76	1.80	1.2	1.2	1.3
PDIA4	2.74	4.57	4.32	1.7	3.0	3.1
PDIA6	1.62	NS	1.98	1.3	1.4	1.4
ERO1L	NS	1.28	1.38	NS	NS	1.2
ERO1LB	2.78	2.13	3.44	ND	ND	ND
Quality Control and Degradation
EDEM1	NS	NS	4.18	ND (1.4)	ND (0.9)	ND (2.5)
EDEM2	2.08	NS	2.13	ND	ND	ND
EDEM3	1.76	NS	1.82	ND	ND	ND
DERLIN2	NS	NS	2.76	ND	ND	ND
SYVN1 (HRD1)	2.07	NS	2.67	ND	ND	ND
VCP (p97)	NS	NS	1.77	1.3	1.3	1.3
HERPUD1	4.19	8.27	8.62	ND	ND	ND
XTP3B	2.27	NS	2.32	ND (1.6)	ND (1.0)	ND (1.9)
OS9	NS	1.60	2.15	ND (0.9)	ND (1.6)	ND (1.6)
SEL1L	1.76	4.36	4.32	NS	NS	2.0
Anterograde Trafficking/Golgi
SEC23B	1.77	NS	1.71	1.6	NS	1.5
SEC24D	5.48	NS	5.60	NS (3.7)	NS (0.9)	NS (3.1)
SEC31A	2.05	NS	2.60	NS	NS	2.0
GOLGB1	1.86	NS	1.81	1.6	NS	1.5
Miscellaneous
DDIT3 (CHOP)	NS	NS	2.67	ND	ND	ND
WIPI1	3.14	3.61	5.71	ND	ND	ND
MSTO1	NS	NS	4.63	ND	ND	ND
SULF1		NS	5.17	ND	ND	ND
CRELD2	3.07	4.80	8.04	ND	ND	ND

NS, not significant; ND, not detected.

^aFDR <0.05.

^bFDR <0.1.

^cQuantity in parentheses is from immunoblotting (see also Figure S2).