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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: J Am Chem Soc. 2013 Jul 3;135(28):10433–10440. doi: 10.1021/ja403042k

Figure 5.

Figure 5

Areas of P450 2B4 showing significant changes in H-D exchange rate are also those showing significant structural movement among conformations represented in the crystal structures of 2B6 as seen from the side (left) and from above the heme (right). A) Overlay of 2B6 complexed with (+)-α-pinene (green) and 2B4 labeled with t-BPA (3R1A, blue); and B) Data for differences in the H-D exchange rate between 2B4 without ligand and covalently labeled with tert-butylphenylacetylene (t-BPA) at the 10000s time point are mapped onto the 2B6 (+)-α-pinene complex.56