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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Clin Cancer Res. 2013 Jun 18;19(16):4422–4432. doi: 10.1158/1078-0432.CCR-13-0788

Figure 2. PPP2R1A depletion leads to persistent radiation-induced DNA damage.

Figure 2

MiaPaCa-2 cells transfected with either si-PPP2R1A or si-NS were treated with radiation and collected 24 hours later for flow cytometric analysis of γH2AX (A, B) and immunoblot analysis of the indicated proteins (C). γH2AX-positive cells are defined by the gates shown (A). Data presented are the mean percentage of γH2AX positive cells ± SE (n = 3) and statistical significance versus IR* is indicated (B). Immunoblots are representative of at least 2 independent experiments.