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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Clin Cancer Res. 2013 Jun 18;19(16):4422–4432. doi: 10.1158/1078-0432.CCR-13-0788

Figure 6. Radiosensitization of MiaPaCa-2 xenografts by LB100.

Figure 6

A, Mice bearing MiaPaCa-2 xenografts (~200 mm3) were treated with a single dose of LB100 (1.5 mg/kg). Tumors (n = 3 per group) were harvested at the indicated time points and assayed for PP2A activity. B and C, Mice bearing MiaPaCa-2, subcutaneous flank xenografts were randomized and treated with PBS (vehicle control), LB100 (1.5mg/kg; Mon-Fri, 2 hours pre-IR), and/or IR (1.2Gy/fraction; Mon-Fri) for 2 cycles. Tumor growth was monitored for 45 days or until the tumors reached approximately 7 times their starting volume, whichever occurred first. Data are the mean tumor volume ± SE obtained from 12 – 16 tumors per treatment condition (B) or are the median time required for tumor volume doubling with upper and lower limits of a 95% confidence interval (C). Statistically significant differences in tumor volume doubling are indicated versus PBS* and IR‡. D, Mice bearing MiaPaCa-2 xenografts (~200 mm3) were treated with a single dose of LB100 and/or IR as illustrated. Tumors (n = 2 per treatment group) were harvested for immunoblotting.