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. 2013 Sep 15;140(18):3731–3742. doi: 10.1242/dev.096560

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© 2013. Published by The Company of Biologists Ltd

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Fig. 3. — Dkk1 overexpression reduces Fgf10 expression and prevents amplification of distal parabronchial smooth muscle cell progenitors. (A-D) β-Gal-stained lungs (A,B) and corresponding vibratome sections through the medial lobes (C,D) of E12.5 control (ctrl) Fgf10^LacZ (A,C) and Rosa26-rtTA;Tet-Dkk1;Fgf10^LacZ lungs (B,D) dox-induced at E10.5. (E-L) Whole-mount in situ hybridization (E,F,I,J) and corresponding vibratome sections (G,H,K,L) for Spry2 (E-H) and Fgfr2b (I-L) on E13.5 ctrl (E,G,I,K) and Rosa26-rtTA;Tet-Dkk1 lungs (F,H,J,L) dox-induced at E10.5. (M,N) Immunostaining for fibronectin (FN) and α-SMA on E13.5 ctrl (M) and Rosa26-rtTA;Tet-Dkk1 (N) lungs dox-induced at E10.5. (O,P) Immunostaining for Pecam on E13.5 ctrl (O) and Rosa26-rtTA;Tet-Dkk1 (P) lungs dox-induced at E10.5. n≥3. Scale bars: 50 μm (C,D,G,H,K,L); 100 μm (M-P).