Table 2.
Impact of a modified reflex algorithm based on different screen result cutoff values
| Parameter | Value for the parametera |
|
|---|---|---|
| Original algorithm | Modified algorithm | |
| No. of samples reflexed (screen IgM+) | 266 | 93 |
| No. of screen IgM+ IgG− samples | 205 | 79 |
| No. of SNV IgM+ samples (no. confirmed positive) | 7 (1) | 11 (4)b |
| No. of screen IgM+ IgG+ samples | 61 | 14 |
| No. of SNV IgM+ and/or IgG+ samples (no. confirmed positive) | 16 (13) | 11 (9) |
| No. of SNV-infected patients identified | 12 | 11c |
a
A positive screen was identified as an index of >1.10 with the original algorithm and of ≥2.00 with the modified algorithm.
b
Three confirmed positive patients (N2, Y4, and N4) with a screen IgG index of >1.10 but <2.00 were defined as screen IgM+ IgG+ using the original algorithm but were reclassified as screen IgM+ IgG− using the modified algorithm.
c
The serum from the patient who was not identified was collected 3 months after the onset of symptoms.