Fig 1.

Structural models of fHbp. (A) Model of fHbp alone illustrating two domains, N-terminal (blue) and C-terminal (green). Mouse or rabbit fH does not bind to fHbp. In immunized mice or rabbits, epitopes in the fH binding site that are important for eliciting bactericidal antibody are exposed. (B) Model of fHbp in a complex with a fragment of fH (short consensus repeats [SCR] 6 and 7, gray). In humans, the vaccine antigen would be expected to be in a complex with fH and, possibly, mask epitopes in the fH binding site. Models are based on the coordinates of the published crystal structure (44).