Table 1.

Types of NodD1 mutants^a

Class	NodD1 mutation	Location	nod gene expression		DNA binding		Dimerization	Proposed function
			− Luteolin	+ Luteolin	− Luteolin	+ Luteolin
WT	None		Not active	Inducible	Yes	Increased	Yes
I	L69F	LH	Not active	Not active	No	No	Yes	DNA binding
	S104L	RD I	Not active	Not active	No	No	Yes	Inducer binding
	D134N	RD I	Not active	Not active	Yes	Increased	Yes	Oligomerization/inducer binding
	M193I	RD II	Not active	Not active	No	Weak	Yes	Contact RNAP
II	K205N	RD II	Constitutive	Repressed	Very weak	Weak	Yes	Inducer binding
III	L280F	RD I	Not active	Enhanced sensitivity	No	Increased	Yes	Contact RNAP
IV	D284N	RD I	Constitutive	Inducible	No	Increased	Yes	Contact RNAP

^aWT, wild-type; LH, linker helix; RD I, regulatory domain I; RD II, regulatory domain II.