Table 1.

Plasma pharmacokinetic parameters after single-dose intramuscular administration of enrofloxacin (2.5 mg/kg of body weight) to piglets (n = 12)

Pharmacokinetic parametera	Unit	Value ± SD
A	μg/ml	2.19 ± 0.18
Ke	1iter/h	0.13 ± 0.03
Ka	1iter/h	4.97 ± 2.47
Lag time	h	0.02 ± 0.08
t1/2(Ka)	h	0.14 ± 0.03
t1/2(Kb)	h	5.17 ± 1.65
t (peak)	h	0.74 ± 0.11
Cmax	μg/ml	0.74 ± 0.38
AUC	(μg/ml) · h	15.87 ± 3.39
CL/F(s)	ml/kg/h/(μg/ml)	0.33 ± 0.12
V/F(C)	(ml/kg)/(μg/ml)	2.30 ± 0.30
Protein binding	%	41.4–56.6

^aA, zero time intercept for α phase; Ke, elimination rate constant; Ka, absorption rate constant; t_1/2(Ka), half-life of absorption; t_1/2(Kb), half-life of elimination; t (peak), peak time; C_max, peak drug concentration; AUC, area under the drug concentration-time curves; CL/F(s), total body clearance; V/F(C), volume of distribution at steady state.