Table 3.
Performance of microscopy methods compared to that of solid culture in HIV-infected and -uninfected patient groups for results of the first specimen
| Microscopy methoda | Microscopy results (% [95% CI]) for: |
||
|---|---|---|---|
| HIV-positive patients (n = 261) | HIV-negative patients (n = 171) | Total (n = 432) | |
| Centrifugation | |||
| Sensitivity | 45.2 (28.9–61.4) | 57.5 (39.2–75.9) | 50.6 (38.6–62.6) |
| Specificity | 99 (97.3–100) | 99.3 (97.7–100) | 99.1 (98.0–100) |
| PPV | 90.4 (75.5–100) | 95.00 (82.9–100) | 92.6 (83.4–100) |
| NPV | 89.6 (85.4–93.8) | 91.7 (87.2–96.1) | 90.5 (87.5–93.5) |
| Centrifugation with NALC | |||
| Sensitivity | 47.6 (31.3–63.9) | 63.6 (45.7–81.5) | 54.6 (42.7–66.6) |
| Specificity | 99 (97.3–100) | 99.3 (97.7–100) | 99.1 (98.0–100) |
| PPV | 90.9 (76.6–100) | 95.4 (84.4–100) | 93.1 (84.6–100) |
| NPV | 90.0 (85.8–94.2) | 92.8 (88.6–97.0) | 91.2 (88.2–94.1) |
| SMF | |||
| Sensitivity | 61.9 (46.0–77.7) | 81.8 (67.1–96.4) | 70.6 (59.7–81.6) |
| Specificity | 98.5 (96.5–100) | 96.7 (93.7–99.8) | 97.4 (95.7–99.2) |
| PPV | 89.6 (76.8–100) | 84.3 (70.2–98.5) | 85.4 (75.9–95.0) |
| NPV | 92.5 (88.7–96.2) | 96.1 (92.8–99.5) | 94.0 (91.5–96.6) |
a
CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.