Table 4.
Performance of microscopy methods compared to that of solid culture in HIV-infected and -uninfected patient groups for 432 patients, considering positivity of the first and second specimens
| Microscopy methoda | Microscopy results (% [95% CI]) for: |
||
|---|---|---|---|
| HIV-positive patients (n = 261) | HIV-negative patients (n = 171) | Total (n = 432) | |
| Centrifugation | |||
| Sensitivity | 46.9 (32.5–61.7) | 57.1 (39.4–73.7) | 51.2 (40.0–62.3) |
| Specificity | 99.1 (96.6–99.9) | 99.3 (96.0–99.9) | 99.1 (97.5–99.8) |
| PPV | 92 (73.9–98.8) | 95.2 (76.1–99.2) | 93.5 (82.1–98.6) |
| NPV | 89.0 (84.3–92.7) | 90.0 (84.0–94.3) | 89.4 (85.9–92.3) |
| Centrifugation with NALC | |||
| Sensitivity | 49.0 (34.4–63.7) | 62.9 (44.9–78.5) | 54.8 (43.5–65.7) |
| Specificity | 98.6 (95.9–99.7) | 99.3 (96.0–99.9) | 98.9 (97.1–99.7) |
| PPV | 88.9 (70.8–97.5) | 95.7 (78.0–99.3) | 92.0 (80.8–97.7) |
| NPV | 89.3 (84.6–93.0) | 91.2 (85.5–95.2) | 90.1 (86.6–92.9) |
| SMF | |||
| Sensitivity | 57.1 (42.2–71.2) | 74.3 (56.7–87.5) | 64.3 (53.1–74.5) |
| Specificity | 98.6 (95.9–99.7) | 94.9 (89.7–97.9) | 97.1 (94.8–98.6) |
| PPV | 90.3 (74.2–97.9) | 78.8 (61.1–91.0) | 84.4 (73.1–92.2) |
| NPV | 90.9 (86.38–94.3) | 93.5 (88.0–97.0) | 91.9 (88.6–94.4) |
a
CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.