Table 5.
Bacterial prevalence and levels by HOMIM probe analysis in LAP subjects: sites with bone loss versus sites that remained healthya
| Bacterial taxon/a and probe for hybridization | Breakdown presence by: |
Mean HOMIM leveld | |
|---|---|---|---|
| Significantly higher prevalenceb | Significantly higher HOMIM levelc | ||
| Aggregatibacter actinomycetemcomitans HOT-531 probe-AA84 | + | + | High |
| Filifactor alocis HOT-539 probe-AA69 | + | + | High |
| Porphyromonas gingivalis HOT-619 probe-AA93 | + | + | High |
| Streptococcus parasanguinis cluster HOT-057, -411, -721 probe-V77 | + | + | High |
| Veillonella dispar-Veillonella parvula-Veillonella rogosae HOT-158, -160, -161 probe-D96 | + | + | High |
| Campylobacter concisus-Campylobacter rectus HOT-575, -748 probe-T86 | + | High | |
| Campylobacter curvus-C. rectus-Campylobacter showae HOT-580, -748, -763 probe-T87 | + | High | |
| C. curvus-C. rectus-C. showae HOT-580-748-763 probe-X37 | + | High | |
| Eubacterium [XI][G-6] minutum HOT-673 probe-AC65 | + | High | |
| Porphyromonas endodontalis-Porphyromonas sp. HOT-273, -285, -395 probe-W78 | + | High | |
| Tannerella forsythia HOT-613 probe-X56 | + | High | |
| Desulfobulbus sp. HOT-041 probe-K70 | + | + | Low |
| Leptotrichiaceae [G-1] sp. HOT-210, -220 probe-Y92 | + | + | Low |
| Peptostreptococcus [XIII][G-1] sp. HOT-113 probe-P72 | + | + | Low |
| Streptococcus anginosus HOT-543 probe-AB84 | + | + | Low |
| Veillonella atypica HOT-524 probe-W04 | + | + | Low |
| Bacteroidales [G-2] sp. HOT-274 probe-K76 | + | Low | |
| Bifidobacterium animalis HOT-895 probe-AC26 | + | Low | |
| Brevundimonas diminuta HOT-590 probe-AC90 | + | Low | |
| Corynebacterium matruchotii HOT-666 probe-666 | + | Low | |
| Fretibacterium sp. HOT-362 probe-P97 | + | Low | |
| Mogibacterium timidum HOT-042 probe-AB25 | + | Low | |
| Megasphaera sp. HOT-123 probe-Y85 | + | Low | |
| Neisseria pharyngis HOT-729 probe-AD93 | + | Low | |
| Ochrobactrum anthropi HOT-544 probe-AB24 | + | Low | |
| Prevotella sp. HOT-299 probe-X15 | + | Low | |
| Propionibacterium acidifaciens HOT-191 probe-AD69 | + | Low | |
| Rothia dentocariosa-Rothia mucilaginosa HOT-587, -681 probe-E52 | + | Low | |
| Slackia exigua HOT-602 probe-AB52 | + | Low | |
| Selenomonas dianae HOT-139 probe-Q50 | + | Low | |
| Streptococcus cristatus HOT-578 probe-AD89 | + | Low | |
| Treponema denticola HOT-584 probe-O40 | + | Low | |
| Treponema genus all-HOT probe AA63 | + | Low | |
| Treponema cluster: Treponema spp. HOT-250, -251, -252, -253, -254, -255, -256, -508, -517, -518 probe-AC42 | + | Low | |
| Treponema spp. HOT-237-242 probe-F89 | + | Low | |
| Lachnoanaerobaculum saburreum- Lachnoanaerobaculum orale HOT-082, -494 probe-AB50 | − | Low | |
| Peptostreptococcus stomatis HOT-112 probe-AA55 | − | Low | |
| Solobacterium moorei HOT-678 probe-AC02 | − | Low | |
| Gemella morbillorum HOT-046 probe-AB09 | − | − | Low |
| Streptococcus spp. HOT-070, -071 probe-N20 | − | − | Low |
| Streptococcus downei HOT-594 probe-AD67 | − | Low | |
| Prevotella genus most-HOT probe-AA44 | − | Low | |
| Granulicatella elegans HOT-596 probe-AB29 | − | High | |
| Fusobacterium cluster HOT-200, -201, -202, -203, -205, -370, -420, -689 probe-AD99 | − | − | High |
| V. dispar HOT-160 probe-AD63 | − | − | High |
Comparison of sites that show bone loss versus sites that do not in LAP subjects.
A boldface “+” indicates that the corresponding taxon or taxa were among the most prominent taxa at 18 sites that showed the most significant increase in prevalence 6 months prior to bone loss, as opposed to the time bone loss was detected; a lightface “+” indicates that the corresponding taxon or taxa were prevalent but less significant. A boldface “−” indicates that the corresponding taxon or taxa were among the most prominent taxa that showed increased prevalence at the time of bone loss, as opposed to 6 months prior to bone loss; a lightface “−” indicates that the corresponding taxon or taxa were found to be less prevalent at the sites at the time of bone loss than 6 months prior to bone loss. All results were analyzed by chi-square and Fisher's exact tests (P < 0.05).
A boldface “+” indicates that the corresponding taxon or taxa were among the most prominent taxa at 18 sites that showed the most significant increase in HOMIM level 6 months prior to bone loss, as opposed to the time bone loss was detected; a lightface “+” indicates that there was still an increase in HOMIM level but that is was of lesser significance. A boldface “−” indicates that the corresponding taxon or taxa were among the most prominent taxa that showed the most significantly increased HOMIM level at the time of bone loss, as opposed to 6 months prior to detection of bone loss; a lightface “−” indicates that there was found to be less of a HOMIM level increase when levels at the sites at the time of bone loss were compared to levels 6 months prior to bone loss. All results were analyzed by analysis of variance and Tukey-Kramer post hoc testing (P < 0.05).
“High” indicates that HOMIM levels for all sites analyzed for a given organism when averaged were calculated to be ≥1.0. “Low” indicates that HOMIM levels for all sites analyzed for a given organism when averaged were calculated to be <1.0.