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. 2013 Aug;79(16):4774–4785. doi: 10.1128/AEM.00998-13

Table 4.

Transcripts encoding proteasome subunits and related functions elevated after exposure to nTiO2, nZnO, and QDs but not to nAg

Subunit and Augustus v5.0 identifier Gene Annotated function Log2 fold changea
TiO2 ZnO Ag QDs
Proteasomeb
    ≥2 log2 fold increase in expression
        512002 RPN1 26S regulatory subunit 2.47 2.51 −0.01 1.94
        517679 RPN2 26S regulatory subunit 2.49 2.69 1.35 2.65
        523380 RPN3 26S regulatory subunit 2.31 2.31 0.19 1.82
        514973 RPN8 26S regulatory subunit 2.05 1.94 −0.13 1.58
        516310 RPN10 26S regulatory subunit 1.93 2.23 0.13 0.70
        510841 RPN11 26S regulatory subunit 2.40 2.85 0.54 2.58
        517257 RPN12 26S regulatory subunit 1.69 2.38 0.78 0.82
        515497 RPT1 26S regulatory subunit 2.01 1.14 −0.55 1.12
        524554 RPT2 26S regulatory subunit 2.62 1.85 0.28 1.83
        517293 RPT4 26S regulatory subunit 2.10 2.86 0.72 2.29
        517191 POA1 20S alpha subunit A 2.53 1.89 −0.13 1.87
        525502 POA2 20S alpha subunit B 2.58 2.38 0.04 2.02
        511244 POA4 20S alpha subunit D 2.28 1.36 0.28 1.74
        517599 POA5 20S alpha subunit E 2.09 2.09 −0.81 1.87
        523200 20S beta subunit 3 2.79 2.57 −0.55 2.06
        523449 20S beta subunit A1 3.05 2.53 0.45 2.40
        509711 20S beta subunit B, type beta 2 3.02 3.04 0.62 2.23
        515181 20S beta subunit D, type 2 2.50 1.98 −0.55 1.47
        523491 20S beta subunit, type 4 2.17 1.99 0.45 1.20
        525170 26S regulatory subunit N5 2.19 1.85 0.07 1.46
    Comparison group
        518932 RPN6 26S regulatory subunit 1.22 1.69 0.39 1.00
        514567 RPN7 26S regulatory subunit −0.05 0.72 −0.17 0.19
        515904 RPN9 26S regulatory subunit 1.29 1.07 −0.84 1.41
        510008 RPT5 26S regulatory subunit 1.94 1.76 −0.02 1.29
        521984 RPT6 26S regulatory subunit 0.14 0.40 −1.78 0.17
        519364 ANK13 26S regulatory subunit 10 −0.12 1.72 0.68 0.12
        509576 POA3 20S alpha subunit C 1.66 0.87 −0.39 0.44
        523979 POA6 20S alpha subunit F 0.61 0.24 −0.14 0.73
        515372 POA7 20S alpha subunit G 1.85 1.04 0.52 0.42
        522780 20S subunit beta 6 1.05 1.15 −0.22 0.40
        513499 20S beta subunit A2 1.83 0.82 −0.18 0.35
        510489 20S beta subunit E. type beta 5 1.69 1.69 −0.67 1.12
        515638 Activator subunit 4 0.64 −0.69 0.26 0.29
        521702 Component ECM29 1.47 0.72 0.45 0.00
        526137 26S regulatory subunit T3 1.91 1.24 0.23 1.54
Proteasome related
    518726 RB60 Protein disulfide isomerase 1 1.21 2.31 −0.94 0.77
    523252 CDC48 Protein degradation/cell cycle 1.45 2.36 −1.16 1.51
    521048 UFD1 Ubiquitin fusion degradation −1.51 2.23 −2.29 −1.09
    514349 Proteasome assembly chaperone 0.47 1.31 2.26 1.29
a

Boldface data indicate transcripts encoding proteasome subunits that are elevated by ≥2 log2 fold in at least one NP transcriptome.

b

Data for proteasome subunit transcripts are divided into data for transcripts encoding proteasome subunits that are elevated ≥2 log2 fold in the transcriptome produced into response to at least one NP and the remaining proteasome subunit transcripts for comparison.