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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Cancer Res. 2013 Jun 1;73(11):3206–3215. doi: 10.1158/0008-5472.CAN-12-2313

Table 2.

Comparison of diagnostic performance of single-step, two-step and previous Raman algorithms for detection of breast cancer, with and without microcalcifications

Raman Algorithm Classification Scheme SE SP PPV NPV OA
Single-step SVM All tissue sites 62.5% 100% 100% 95.6% 82.2%
Tissue sites with
microcalcifications		 64.3% 100% 100% 92.7% 70.1%
Tissue sites without
microcalcifications		 50% 100% 100% 98.5% 95.7%
Two-step LR-SVM
(naive)		 All tissue sites 53.8% 94% 95% 81.3% 73.4%
Two-step LR-SVM
(optimized)		 All tissue sites 56.3% 100% 100% 94.9% 80%
Previous SVM
algorithma 		All tissue sites 62.5% 100% 100% 95.6% 81.5%
Previous LR
algorithmb 		83% 93% 36% 99% 78.3%
a

SVM Raman algorithm for the diagnosis of breast cancer irrespective of microcalcification status (29)

b

LR Raman algorithm for the diagnosis of breast cancer in the absence of microcalcifications (17)