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. Author manuscript; available in PMC: 2014 Jul 11.
Published in final edited form as: J Phys Chem B. 2013 Jul 1;117(27):8180–8188. doi: 10.1021/jp402632a

Table 3.

Sign of Desolvation Free Energy Determines Concentration Effect on Equilibrium

sign of ΔGH2O consequence of [Q]ieq ↑ binding pair example
(+) Ki ↓ EDTA:Ca2+
~0 Ki constant many?
(−) Ki ↑ two nonpolar solutes