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. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: Pediatr Res. 2009 Apr;65(4):437–442. doi: 10.1203/PDR.0b013e3181994fa0

Comparison of HB-EGF and EGF in prevention of NEC. (A) NEC Scores. Either equal molar (800 μg/kg/dose HB-EGF versus 570 μg/kg/dose EGF) or equal mass (800 μg/kg/dose HB-EGF versus 800 μg/kg/dose EGF) amounts of HB-EGF and EGF were compared in their ability to prevent NEC. Each dot represents a single rat pup exposed to experimental NEC, and the NEC score for each pup is shown. (B) Incidence of NEC. The percent of animals with NEC in pups that received either equal molar or equal mass amounts of HB-EGF or EGF is shown. *p < 0.05 compared with the non-growth factor-treated control group; §, not significant; N/A, no addition of HB-EGF to feeds. Grade 2 NEC, ; grade 3 NEC, .

Inline graphic — Comparison of HB-EGF and EGF in prevention of NEC. (A) NEC Scores. Either equal molar (800 μg/kg/dose HB-EGF versus 570 μg/kg/dose EGF) or equal mass (800 μg/kg/dose HB-EGF versus 800 μg/kg/dose EGF) amounts of HB-EGF and EGF were compared in their ability to prevent NEC. Each dot represents a single rat pup exposed to experimental NEC, and the NEC score for each pup is shown. (B) Incidence of NEC. The percent of animals with NEC in pups that received either equal molar or equal mass amounts of HB-EGF or EGF is shown. *p < 0.05 compared with the non-growth factor-treated control group; §, not significant; N/A, no addition of HB-EGF to feeds. Grade 2 NEC, ; grade 3 NEC, .