Table 2.
Contribution of Ktr to antimicrobial resistance.
| Antibiotic | MIC Values | |||||
|---|---|---|---|---|---|---|
| 0.5 mM KCl | 10 mM KCl | |||||
| LAC (pCM28) | ΔktrA (pCM28) | ΔktrA (+ktrA) | LAC (pCM28) | ΔktrA (pCM28) | ΔktrA (+ktrA) | |
| Gentamicin | 0.5 | <0.0625 | 0.5 | 0.5 | 0.25 | 0.5 |
| Tobramycin | 1 | 0.125 | 1 | 1 | 0.5 | 1 |
| Polymyxin B | 32 | 8 | 32 | 32 | 16 | 32 |
| LL-37 | 256 | 16 | 256 | 512 | 64 | 512 |
| HNP-1 | 6 | 1.5 | 6 | 6 | 3 | 6 |
| Vancomycin | 2 | 1 | 2 | 2 | 1 | 2 |
| Gramicidin | >64 | <1 | >64 | >64 | 32 | >64 |
| Valinomycin | >64 | >64 | >64 | 4 | 2 | 4 |
a
MIC values reported are the concentration of antibiotic in which no growth was seen following 20 hrs of static incubation at 37°C.
b
Results are representative of at least two independent experiments.