Figure 4.

Seed-based cross-correlation analysis of deactivation network in 48 matched subjects in 201 acupuncture runs with deqi and 74 tactile stimulation runs with and without deqi. Reference regions are circled in red, and regions with positive correlation activity are circled in green. Correlations with p<0.001 are shown. (A, B) Correlations for the posterior cingulate Brodmann area 31: (A) Acupuncture: reference voxel (2, −53, 36), showing correlations in the medial prefrontal, posterior medial parietal, medial temporal lobe and temporal pole. (B) Tactile stimulation: reference voxel (3, −63, 31), showing correlations that partially overlap those in acupuncture, but correlations are markedly weaker. (C,D) Correlations for the hypothalamus: (C) Acupuncture: reference voxel (3, −1, −10), showing correlations with regions similar to (A), but more limited in extent. (D) Tactile stimulation: reference voxel (3, −1, −10), showing no regions with significant signal change. Numbered areas: (1) frontal pole and pregenual cingulate, (2) subgenual cingulate, and subgenual area 25 in the ventral route of the medial prefrontal cortex, (3) precuneus, posterior cingulate and retrosplenial cortex of the posterior medial parietal cortex, (4) amygdala, hippocampus, and parahippocampus of the medial temporal lobe, (5) temporal pole, (6) precuneus and posterior cingulate cortex Brodmann area 31, and (7) orbitofrontal cortex, subgenual cingulate, subgenual area SG25 and ventromedial prefrontal cortex.