Fig. 3.

Representative mouse 5-HT2C-VNV-mediated PLC functional data showing the effects of co-administration of 500 nM (−)-PAT (A), 1-methylpsilocin (B), or mCPP (C) with DOI on the ability of DOI to stimulate 5-HT2C receptor-mediated inositol phosphate (IP) production in HEK cells. Note that each of the selective 5-HT2C agonists significantly suppressed the maximal IP response to DOI.