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Anti-proliferative effect of cerulenin. (A) LiSa-2 cells were grown for 5 days in the indicated concentrations of cerulenin with or without 32 μM palmitate. DNA content/well was assessed using the Hoechst assay. (B and C) Replicated experiment in SW872 and fibroblast cells. Data are mean ± SEM normalized to the control group; n=8/group. *p<0.0001 comparing cerulenin treatment to control; #p<0.03 comparing palmitate with cerulenin to corresponding cerulenin dose alone.
