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. 2013 Aug 26;210(9):1839–1854. doi: 10.1084/jem.20122588

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© 2013 Guy-Grand et al.

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Figure 6. — Cycling SI-Ep immigrants are the precursors of Granzyme B^high cells. (A) Flow cytometric analysis of the expression levels of Granzyme B in normal IELs and MLNs (15 mice in 15 independent experiments). (B) Structural analysis of Granzyme B content with ImageStream system (Amnis) in the indicated subsets of CD3⁺ IELs, as defined in the accompanying dot plot (one experiment [preliminary]). (C) Dot plots correlating CD69 expression and levels of Granzyme B in the indicated CFSE generations of donor γδ or CD8αβ SI-Ep immigrants. Data are representative of seven recipients individually analyzed at days 4–8 after transfer, in seven independent experiments.