Table 1.
Apc mutant mouse lines
| Allele | Truncation codon | Conditional? | Genetic Background |
Intestinal Tumor # |
% of wt protein per allele |
Initial Reference of Phenotype |
|---|---|---|---|---|---|---|
| Δ468 | 468 (armadillo repeats) | Yes | N/Av | N/Av | N/Av | Gounari et al., 200574 |
| Δ474 | 474 (armadillo repeats) | No | B6 | >100 | 100 | Sasai et al., 200064 |
| Δ14 | 580 (armadillo repeats) | Yes | B6 | >100 | 100 | Colnot et al., 200465 |
| 580S | 580 (armadillo repeats) | Yes | Mixed | N/Av | N/Av | Shibata et al., 199775 |
| Δ716 | 716 (armadillo repeats) | No | B6 | >100 | 0* | Oshima et al., 1995149 |
| lacZ | 716 (armadillo repeats) | No | Mixed | >100 | 100 | Ishikawa et al., 2006150 |
| Min | 850 (armadillo repeats) | No | B6 | >100 | 100 | Moser et al., 199062 |
| Δ1309 | 1309 (15aa repeats) | No | B6 | 40 | 100 | Niho et al., 200368 |
| 1638N | 1638 (SAMP repeats) | No | B6 | 1 | 2 | Fodde et al., 199469 |
| 1638T | 1638 (SAMP repeats) | No | B6 | 0 | 100 | Smits et al., 199970 |
| Ex13 NeoR | full-length | No | B6 | 1 | 20 | Li et al., 200571 |
| Ex13 NeoF | full-length | No | B6 | 0.3 | 10 | Li et al., 200571 |
*
This is suggested, but not proven.71
N/Av = not available.