Table 2. REV publication timeline.
Number | Virus | Secondary Association | Host Species | Host Animal Status | Year | Country | Method(s) of REV Detection | Ref. |
1* | NK | P. lophurae | Duck | Experimental | 1941 | US | F | [49] |
2* | NK | P. lophurae | Duck | Experimental | 1945 | US | F | [30] |
3† | FWPV-REV | 1949 | US | E | [52] | |||
4† | SNV | P. lophurae | Duck | Experimental | 1958 | US | A | [28] |
5 | REV | Turkey | Domestic | 1958 | US | A | [2] | |
6 | NK | P. lophurae | Duck | Experimental | 1966 | US | F | [66] |
7† | CSV | Chicken | 1969 | US | A | [67] | ||
8 | DIAV | P. lophurae | Duck | Experimental | 1971 | US | A, C, D | [32] |
9 | REV | Japanese quail | Domestic | 1972 | CA | D | [68] | |
10† | REV | Duck | Wild | 1973 | AU | C, D | [69] | |
11 | REV | Muscovy duck | Domestic | 1974 | US | C, D | [70] | |
12† | REV | Japanese quail | Domestic | 1974 | MX | C, D | [71] | |
13 | REV | Turkey | Domestic | 1974 | US | A, D | [72] | |
14 | REV | GHV-2 vaccine | Chicken | Domestic | 1974 | JP | A, B, C, D | [15] |
15 | REV | HVT vaccine | Turkey | Domestic | 1975 | JP | A | [73] |
16 | REV | Turkey | Domestic | 1975 | UK | A, C, D | [74] | |
17 | REV | Turkey | Domestic | 1976 | US | C, D | [75] | |
18 | REV | FWPV | Turkey | Domestic | 1976 | CA | B, C | [34] |
19† | REV | Chicken | Domestic | 1978 | AU | C, D | [76] | |
20 | SNV (RU1) | P. lophurae | Duck | Experimental | 1983 | US | A, C, D | [31] |
21 | REV | FWPV | Pheasant | Domestic | 1983 | HU | A, B, C, D | [35] |
22 | REV | Chicken | Domestic | 1984 | US | A, C | [77] | |
23 | REV | Turkey | Domestic | 1988 | HU | F | [78] | |
24 | REV | Goose | Domestic | 1989 | HU | A, C, D | [79] | |
25† | REV | Turkey | Wild | 1989 | US | D | [80] | |
26† | REV | Turkey | Wild | 1992 | US | A, C | [81] | |
27† | GHV-2-REV | GHV-2 vaccine | 1993 | US | E | [54] | ||
28† | REV | FWPV vaccine | Chickens | Domestic | 1996 | US | C, E | [82] |
29 | REV | FWPV vaccine | Chickens | Domestic | 1997 | AU | E | [12] |
30 | REV | Indian peafowl | Domestic | 1998 | US | F | [83] | |
31† | REV | FWPV | Various | Wild/Domestic | 1998 | AU | A, E | [17] |
32† | REV | FWPV | Prairie chickens | Domestic | 1998 | US | C, D, E | [37] |
33 | GHV-2-REV | Turkey, chicken | Domestic | 1999 | US | E | [84] | |
34 | FWPV-REV | FWPV vaccine | 2000 | US | E | [18] | ||
35 | REV | Wild turkeys | Wild | 2002 | US | E | [85] | |
36† | REV | Turkey | Domestic | 2002 | US | C, E | [86] | |
37† | REV | Partridge | Domestic | 2002 | US | B, C | [38] | |
38† | REV | Chickens | 2003 | US | E | [87] | ||
39† | FWPV-REV | Various | 2003 | US | E | [16] | ||
40 | REV | Chickens | Domestic | 2006 | CN | A, E | [39] | |
41 | REV | HVT, GHV-2, FWPV vaccines | Chickens | Domestic | 2006 | TW | C, E | [88] |
42 | REV | Prairie chicken | Captive | 2006 | US | A, E | [89] | |
43 | REV | FWPV | Turkey, chicken | Domestic | 2006 | HR | E | [90] |
44 | REV | FWPV vaccines | Chickens | Domestic | 2006 | CN | E | [91] |
45† | FWPV-REV | Chickens | Domestic | 2007 | US | E | [92] | |
46 | REV | Chinese partridge | Domestic | 2007 | CN | A, C, D, E | [93] | |
47 | REV | FWPV, HVT vaccines | Domestic | 2009 | CN | E | [94] | |
48 | REV | Goose | Domestic | 2009 | CN | A, D, E | [95] | |
49 | REV | FWPV vaccine | 2010 | EG | D, E | [96] | ||
50† | FWPV-REV | Chickens | Domestic | 2010 | GD | A, E | [97] | |
51† | FWPV-REV | Chickens | Domestic | 2010 | AU | A, B, D, E | [98] | |
52 | FWPV-REV | Chickens | Domestic | 2011 | IN | D, E | [19] |
A comprehensive list of published studies in which REV has been detected, isolated, or otherwise implicated, either as an exogenous retrovirus or as an endogenous insert in the FWPV or GHV-2 genomes. Numbers in the first column cross-reference to Figure 7. The primary virus implicated, isolated, or detected in each published report is shown. Exogenous REV strains are shown in bold, and DNA viruses with REV insertions are shown in italics. Where primary virus occurred in the context of contaminated vaccine or with another infectious agent, details of these secondary associations are shown. Infected host species are indicated, along with the status of the animal (domestic/experimental/captive/wild). The country and year in which the primary virus was implicated, isolated, or detected are shown (countries are shown as two-letter ISO country codes). Where reported/applicable, methods of REV detection used in each report are provided as follows: A, isolation & passage; B, electron microscopy; C, serology; D, histopathology; E, PCR and/or sequencing; F, disease pathology (where no other methods used). Serological surveys of REV antigens (see Table S5) are not included here.
Reports in which presence of REV was not confirmed.
Studies for which we have confirmed all samples have been exhausted or destroyed.
Abbreviations: SNV, spleen necrosis virus; DIAV, duck infectious anemia virus; FWPV-REV, Fowlpox virus with REV insertion; GHV-2-REV, gallid herpesvirus type 2 with REV LTR insertion; HVT, herpesvirus of turkeys; N/K, not known.