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. 2013 Aug 27;8(8):e73684. doi: 10.1371/journal.pone.0073684

Figure 3. Reducing bioavailable copper slows tumor growth rate.

Figure 3

AE17-bearing mice were given daily PBS, TM (500 µg/dose/mouse), penicillamine (2000 µg/dose/mouse) and trientine (700 µg/dose/mouse) throughout tumor growth (A). Pooled data is from one experiment (n = 4 or 5 mice/group). In a separate experiment, AE17-bearing mice were given cisplatin, TM or PBS; n = 6 mice/group (B). In another experiment AE17-bearing mice were given i.p. injections (800 µl) of PBS or 800 µg/dose/mouse anti-VEGFr antibody (C) (n = 10 mice/group). Arrow indicates when treatment was commenced. All data are shown as mean ± SEM. * p < 0.05.