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. 2013 Aug 27;8(8):e73839. doi: 10.1371/journal.pone.0073839

Figure 4. Effect of blockage of COX on hypoxic vasoconstriction in IPAs.

Figure 4

a. Indomethacin, a nonspecific antagonist of COX, almost abolished hypoxic vasoconstriction in IPAs and exerted slight inhibition on KPSS induced vessel contraction. b. NS398, a specific antagonist of COX-2, abolished phase II of hypoxic vasoconstriction and significantly inhibited phase I of hypoxic vasoconstriction. c. DuP697, a highly selective and irreversible inhibitor of COX-2, abolished phase I of hypoxic vasoconstriction. d. Valeryl Salicylate, a highly selective antagonist of COX-1, attenuated KPSS induced vessel contraction.