Table 5.
Significant covariates for the univariate and multivariate analysis.
| Significant covariates | ΔMOFV | P-value |
|---|---|---|
| Univariate analysis | ||
| Effect of CYP3A5 expressers on CL/F | −27.64 | < 0.001 |
| Effect of age on CL/F | −16.42 | < 0.001 |
| Effect of CYP3A4*1B carriers on CL/F | −12.95 | < 0.001 |
| Effect of MRP2 high activity group on CL/F | −11.45 | < 0.001 |
| Effect of Caucasian on CL/F | −7.24 | < 0.01 |
| Effect of diabetes mellitus on lag time | −12.96 | < 0.001 |
| Multivariate analysis | ||
| Effect of CYP3A5 expressers on CL/F | +37.02 | < 0.001 |
| Effect of MRP2 high activity group on CL/F | +10.02 | < 0.005 |
| Effect of age on CL/F | +22.42 | < 0.001 |
| Effect of diabetes mellitus on lag time | +25.69 | < 0.001 |
MOFV, minimum objective function value; CYP, cytochrome P450; CL/F, apparent oral clearance; MRP2, multidrug resistance-associated protein 2