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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Virology. 2013 Jun 16;444(0):71–79. doi: 10.1016/j.virol.2013.05.034

Figure 3. Disease, mortality and CNS replication following HSV-1 replication in C57BL6, IRF-3−/− , IRF-7−/− or IRF-3/7−/− (DKO) mice.

Figure 3

(A) Pathology following HSV-1 infection. Corneas of C57BL6, IRF-3−/− , IRF-7−/− and DKO mice were scarified and inoculated with 2 × 106 pfu/eye. Disease scores were recorded in accordance with parameters detailed in the materials and methods. Data represents disease scores from three independent experiments (n ≥ 12 mice per group). (B) Survival of wild-type, IRF-3−/−, IRF-7−/− and DKO mice following corneal infection with 2 × 106 p.f.u HSV-1 strain 17 per eye. Survival curves were carried out independent of other studies and represent data from three individual experiments. (n ≥ 12 mice per group). Brain stems (C) and brains (D) were harvested at specified days following infection of wild-type, IRF-3−/− , IRF-7−/− and DKO mice with 2 × 10 p.f.u. HSV-1 strain 17 per eye. Graphs represent mean +/− SEM of two independent experiments, (n ≥ 5 mice per group)