Figure 1. Anti-invasive compounds. (A) More traditional routes to halt invasion of cancer cells include targeting the cytoskeleton (microtubules, actin, and associated myosin machinery), cell adhesions and their activators, and matrix degradation enzymes. (B) Newer treatment options for halting invasion include more diverse targets, including upstream inactivation routes including receptor tyrosine kinases and chemokine receptors, ion, and water channels, transcription factors such as HIF-1α, and inflammation driven progression through reactive oxygen species (ROS).