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Figure 7. Model of CASZ1 function in cell cycle regulation. Restoration of CASZ1 in NB cells results in upregulation of p21 a Cdk2/4 inhibitor and downregulation of cyclins such as Cyclin D1 and Cdk2/6. Thus CASZ1 inhibits Cdk enzyme activity, resulting in hypo-phosphorylation of pRb that binds E2F, thus decreasing E2F-mediated transcription and restoring the G1–S checkpoint and inhibition of cell cycle progression.
