. Author manuscript; available in PMC: 2013 Aug 27.

Published in final edited form as: Bioorg Med Chem. 2008 Oct 29;16(24):10210–10215. doi: 10.1016/j.bmc.2008.10.056

Table 2.

¹H NMR spectral data of the target compounds.

Compound	δ (number of protons, multiplicity, J in Hz, proton assignment)
4a	8.12–7.92 (2H, m, ArH); 7.87 (1H, m, ArH); 7.68–7.46 (6H, m, ArH, SONH₂); 7.35–7.29 (2H, m, ArH); 7.14–7.05 (3H, m, ArH, COOH); 4.01 (2H, s, CH₂); 2.97 (2H, t, 7.5, CH₂CH₂CH₂CH₃); 1.97 (2H, qv, 7.5, CH₂CH₂CH₂CH₃); 1.45 (2H, sx, 7.5, CH₂CH₂CH₂CH₃) and 0.97 (3H, t, 7.5, CH₂CH₂CH₂CH₃)
4b	8.03–7.96 (2H, m, ArH); 7.86 (1H, s, br, COOH); 7.76–7.74 (1H, m, ArH); 7.61–7.50 (4H, m, ArH); 7.48–7.42 (2H, m, ArH); 7.36–7.29 (2H, m, ArH); 7.17 (1H, s, br, SONH); 4.04 (2H, s, CH₂); 2.58 (3H, s); 2.25 (2H, t, 7.5, CH₂CH₂CH₂CH₃); 1.63 (2H, qv, 7.5, CH₂CH₂CH₂CH₃); 1.35 (2H, sx, 7.5, CH₂CH₂CH₂CH₃) and 0.98 (3H, t, 7.5, CH₂CH₂CH₂CH₃)
4c	8.25–7.70 (5H, m, br, ArH, COOH, SONH); 7.62–7.29 (8H, m, ArH); 4.04 (2H, s, CH₂); 3.03 (2H, t, 7.5, CH₂CH₂CH₂CH₃); 2.94 (2H, q, 7, CH₂CH₃); 2.59 (2H, qv, 7.5, CH₂CH₂CH₂CH₃); 2.02 (2H, sx, 7.5, CH₂CH₂CH₂CH₃); 1.28 (3H, t, 7, CH₂CH₃) and 0.98 (3H, t, 7.5, CH₂CH₂CH₂CH₃)
4d	7.97–7.70 (5H, m, ArH, COOH, SONH); 7.64–7.54 (4H, m, ArH); 7.52–7.44 (2H, m, ArH); 7.33 (2H, m, ArH); 4.05 (2H, s, CH₂); 3.06 (2H, t, 7.5, CH₂CH₂CH₂CH₃); 3.03 (2H, t, 7.2, CH₂CH₂CH₃); 2.62 (2H, sx, 7.2, CH₂CH₂CH₃); 1.74 (2H, qv, 7.5, CH₂CH₂CH₂CH₃); 1.69 (3H, t, 7.2, CH₂CH₂CH₃); 1.64 (2H, sx, 7.5, CH₂CH₂CH₂CH₃) and 0.90 (3H, t, 7.5, CH₂CH₂CH₂CH₃)
4e	8.05–7.90 (3H, br, m, COOH, NH, ArH); 7.76–7.74 (1H, m, ArH); 7.73–7.26 (9H, m, ArH); 4.0 (2H, d, 6, CH₂); 3.70 (1H, sp, 7.5, CH(CH₃)₂); 3.24 (2H, t, 7, CH₂CH₂CH₂CH₃); 1.43 (6H, d, 7.5, CH(CH₃)₂); 1.95 (2H, qv, 7, CH₂CH₂CH₂CH₃); 1.45 (2H, sx, 7, CH₂CH₂CH₂CH₃) and 0.99 (3H, t, 7, CH₂CH₂CH₂CH₃).
4f	8.06–8.18 (1H, br, s, COOH); 7.75–7.62 (3H, m, ArH and SO₂NH); 7.55–7.31 (9H, m, ArH); 4.04 (2H, d, 6, CH₂); 3.21 (4H, m, CH₂ CH₂ CH₂ CH₃); 1.71 (4H, m, CH₂CH₂CH₂CH₃); 1.41 (4H, m, CH₂CH₂CH₂CH₃) and 0.96 (6H, m, CH₂CH₂CH₂CH₃)
4g	8.0–7.32 (13H, br, m, COOH, SO₂NH and ArH); 4.0 (2H, d, 6, CH₂); 3.02 (2H, t, 7, CH₂CH₂CH₂CH₃); 2.1 (9H, s, C(CH₃)₃); 1.93 (2H, qv, 7, CH₂CH₂CH₂CH₃); 1.47 (2H, sx, 7, CH₂CH₂CH₂CH₃) and 0.99 (3H, t, 7, CH₂CH₂CH₂CH₃)
4h	8.1–7.58 (8H, br, m, COOH, SO₂NH and ArH); 7.64–7.31 (5H, br, m, ArH); 4.02 (2H, d, 6, CH₂); 4.4 (1H, m, CH); 3.25 (2H, t, 7, CH₂CH₂CH₂CH₃); 2.27–1.17 (10H, m, (CH₂)₅); 1.95 (2H, qv, 7, CH₂CH₂CH₂CH₃); 1.43 (2H, sx, 7, CH₂CH₂CH₂CH₃) and 0.96 (3H, t, 7, CH₂CH₂CH₂CH₃)
5	8.12–7.90 (1H, m, ArH); 7.69–7.74 (1H, m, ArH); 7.63–7.58 (2H, m, ArH, COOH); 7.56–7.51 (4H, m, ArH); 7.48–7.39 (3H, m, ArH, SO₃H); 7.35–7.28 (2H, m, ArH); 4.25 (2H, s, CH₂); 2.95 (2H, t, 7.5, CH₂CH₂CH₂CH₃); 1.67 (2H, qv, 7.5, CH₂CH₂CH₂CH₃); 1.35 (2H, sx, 7.5, CH₂CH₂CH₂CH₃) and 0.97 (3H, t, 7.5, CH₂CH₂CH₂CH₃)