Table 3.
Islet Function Status According to Number of IE/Kg Transplanted
| 6 Month Follow-up | 12 Month Follow-up | 24 Month Follow-up | 36 Month Follow-up | C-Peptide Positive* (> 0.6 ng/ml) | % w/mean HbA1c < 7.0%** | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| % | (N) | |||||||||
| < 2500 IE/Kg | (75) | (75) | (54) | (33) | 79% | 71% | ||||
| Insulin Independent | 13% | (10) | 13% | (8) | 15% | (8) | 12% | (4) | ||
| Partial Function | 56% | (42) | 53% | (40) | 48% | (26) | 33% | (11) | ||
| Insulin Dependent | 31% | (23) | 36% | (27) | 37% | (20) | 55% | (18) | ||
|
| ||||||||||
| 2500–5000 IE/Kg | (82) | (83) | (62) | (37) | 97% | 86% | ||||
| Insulin Independent | 20% | (16) | 23% | (19) | 31% | (19) | 22% | (8) | ||
| Partial Function | 78% | (64) | 72% | (60) | 60% | (37) | 62% | (23) | ||
| Insulin Dependent | 2% | (2) | 5% | (4) | 10% | (6) | 16% | (6) | ||
|
| ||||||||||
| >5000 IE/Kg | (49) | (49) | (31) | (25) | 100% | 94% | ||||
| Insulin Independent | 31% | (15) | 55% | (27) | 65% | (20) | 72% | (18) | ||
| Partial Function | 67% | (33) | 43% | (21) | 32% | (10) | 24% | (6) | ||
| Insulin Dependent | 2% | (1) | 2% | (1) | 3% | (1) | 4% | (1) | ||
*
Percent of patients in each islet yield category with C-Peptide Positive values greater than 0.6 ng/ml
**
Percent of patients in each islet yield category with mean Hb/A1c levels over time at less than 7.0%