Table I.
Initial Composition of Enalapril Pellets Obtained by Extrusion–Spheronization
| Formulations | EM (%,w/w) | NaHCO3 (%, w/w) | SA (%, w/w) | MCC (%, w/w) | CROS (%, w/w) | Polysorbatea (mL) |
|---|---|---|---|---|---|---|
| EMC | 5 | – | – | 90 | 5 | 106 |
| EMSA1 | 5 | – | 10 | 80 | 5 | 103 |
| EMSA2 | 5 | – | 20 | 70 | 5 | 74 |
| NaEC | 5 | 2.5 | – | 87.5 | 5 | 106 |
| NaESA | 5 | 2.5 | 10 | 77.5 | 5 | 89 |
EM enalapril maleate, NaHCO 3 sodium hydrogen carbonate, SA stearic acid, MCC microcrystalline cellulose, CROS crospovidone, EMC conventional pellets containing enalapril maleate, EMSA pellets containing EM and SA, NaEC conventional pellets containing NaE, NaESA pellets containing NaE and SA
a1% (v/v) polysorbate aqueous solution