Table IV.
Melting Point and Enthalpy of Fusion of the Indomethacin
| Material | Melting point (°C) ± DP | ΔH (J/g) ± DP | % theoretical value expected |
|---|---|---|---|
| INDN | 160.53 ± 0.10 | −115.81 ± 3.20 | 100.00 |
| IND-SD | 159.96 ± 0.06 | −110.58 ± 2.23 | 95.50 ± 1.92 |
| IND-SB | 160.27 ± 0.15 | −105.26 ± 0.18 | 90.90 ± 0.15 |
| IND-CAS | 158.83 ± 0.19 | −28.83 ± 4.96 | 78.20 ± 13.4a |
| MP-SD | 159.26 ± 0.31 | −28.43 ± 4.31 | 77.13 ± 14.9a |
| MP-SB | 157.58 ± 0.22 | −4.25 ± 0.11 | 12.11 ± 0.38a |
INDN non-processed indomethacin free crystals, IND-SD spray-dried free indomethacin, IND-SB spouted bed-dried free indomethacin, IND-CAS physical indomethacin/casein mixture (1:2, w/w), MP-SD spray-dried microparticles, MP-SB spouted bed-dried microparticles
aRelated to the expected enthalpy of fusion of the spray-dried indomethacin crystals